Ontology highlight
ABSTRACT:
SUBMITTER: Blanton S
PROVIDER: S-EPMC360275 | biostudies-other | 1992 Sep
REPOSITORIES: biostudies-other
Blanton S S Srinivasan A A Rymond B C BC
Molecular and cellular biology 19920901 9
An essential pre-mRNA splicing factor, the product of the PRP38 gene, has been genetically identified in a screen of temperature-sensitive mutants of Saccharomyces cerevisiae. Shifting temperature-sensitive prp38 cultures from 23 to 37 degrees C prevents the first cleavage-ligation event in the excision of introns from mRNA precursors. In vitro splicing inactivation and complementation studies suggest that the PRP38-encoded factor functions, at least in part, after stable splicing complex format ...[more]