Ontology highlight
ABSTRACT:
SUBMITTER: Simmons DL
PROVIDER: S-EPMC360319 | biostudies-other | 1992 Sep
REPOSITORIES: biostudies-other
Molecular and cellular biology 19920901 9
Early-growth-response genes, also known as immediate-early genes, play important roles in regulating cell proliferation. We have identified a new type of early-growth-response gene product, a 77,811-Da putative serine/threonine kinase, which is highly inducible by serum and phorbol ester. mRNA encoding this putative kinase is markedly elevated within 1 h after treatment with mitogen, and this induction is synergistically increased by cycloheximide. Dexamethasone blocks serum induction of the kin ...[more]