Ontology highlight
ABSTRACT:
SUBMITTER: Vincentz JW
PROVIDER: S-EPMC3605159 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Vincentz Joshua W JW Firulli Beth A BA Lin Andrea A Spicer Douglas B DB Howard Marthe J MJ Firulli Anthony B AB
PLoS genetics 20130321 3
Neural crest cells are multipotent progenitor cells that can generate both ectodermal cell types, such as neurons, and mesodermal cell types, such as smooth muscle. The mechanisms controlling this cell fate choice are not known. The basic Helix-loop-Helix (bHLH) transcription factor Twist1 is expressed throughout the migratory and post-migratory cardiac neural crest. Twist1 ablation or mutation of the Twist-box causes differentiation of ectopic neuronal cells, which molecularly resemble sympathe ...[more]