Ontology highlight
ABSTRACT:
SUBMITTER: Morgan MR
PROVIDER: S-EPMC3605578 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Morgan Mark R MR Hamidi Hellyeh H Bass Mark D MD Warwood Stacey S Ballestrem Christoph C Humphries Martin J MJ
Developmental cell 20130228 5
Precise spatiotemporal coordination of integrin adhesion complex dynamics is essential for efficient cell migration. For cells adherent to fibronectin, differential engagement of α5β1 and αVβ3 integrins is used to elicit changes in adhesion complex stability, mechanosensation, matrix assembly, and migration, but the mechanisms responsible for receptor regulation have remained largely obscure. We identify phosphorylation of the membrane-intercalated proteoglycan syndecan-4 as an essential switch ...[more]