Ontology highlight
ABSTRACT:
SUBMITTER: Jaaro-Peled H
PROVIDER: S-EPMC3605832 | biostudies-other | 2013 Apr
REPOSITORIES: biostudies-other
Jaaro-Peled Hanna H Niwa Minae M Foss Catherine A CA Murai Rina R de Los Reyes Samantha S Kamiya Atsushi A Mateo Yolanda Y O'Donnell Patricio P Cascella Nicola G NG Nabeshima Toshitaka T Guilarte Tomás R TR Pomper Martin G MG Sawa Akira A
Human molecular genetics 20130111 8
Imaging of the human brain has been an invaluable aid in understanding neuropsychopharmacology and, in particular, the role of dopamine in the striatum in mental illness. Here, we report a study in a genetic mouse model for major mental illness guided by results from human brain imaging: a systematic study using small animal positron emission tomography (PET), autoradiography, microdialysis and molecular biology in a putative dominant-negative mutant DISC1 transgenic model. This mouse model show ...[more]