Ontology highlight
ABSTRACT:
SUBMITTER: Wu CT
PROVIDER: S-EPMC361188 | biostudies-other | 1991 Aug
REPOSITORIES: biostudies-other
Wu C T CT Budding M M Griffin M S MS Croop J M JM
Molecular and cellular biology 19910801 8
Mammalian multidrug-resistant cell lines, selected for resistance to a single cytotoxic agent, display cross-resistance to a broad spectrum of structurally and functionally unrelated compounds. These cell lines overproduce a membrane protein, the P-glycoprotein, which is encoded by a member(s) of a multigene family, termed mdr or pgp. The amino acid sequence of the P-glycoprotein predicts an energy-dependent transport protein with homology to a large superfamily of proteins which transport a wid ...[more]