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In non-severe hemophilia A the risk of inhibitor after intensive factor treatment is greater in older patients: a case-control study.

ABSTRACT: Twenty-five percent of new anti-factor VIII (FVIII) antibodies (inhibitors) that complicate hemophilia A occur in those with mild and moderate disease. Although intensive FVIII treatment has long been considered a risk factor for inhibitor development in those with non-severe disease, its strength of association and the influence of other factors have remained undefined. To evaluate risk factors for inhibitor development in patients with non-severe hemophilia A. Information on clinical and demographic variables and FVIII genotype was collected on 36 subjects with mild or moderate hemophilia A and an inhibitor and 62 controls also with mild or moderate hemophilia A but without an inhibitor. Treatment with FVIII for six or more consecutive days during the prior year was more strongly associated with inhibitor development in those ≥30years of age compared with those <30years of age [adjusted odds ratio (OR) 12.62; 95% confidence interval (CI), 2.76-57.81 vs. OR 2.54; 95% CI, 0.61-10.68]. Having previously received <50days of FVIII was also not statistically associated with inhibitor development on univariate or multivariate analysis. These findings suggest that inhibitor development in mild and moderate hemophilia A varies with age, but does not vary significantly with lifetime FVIII exposure days: two features distinct from severe hemophilia A.

SUBMITTER: Kempton CL

PROVIDER: S-EPMC3612936 | biostudies-other | 2010 Oct

REPOSITORIES: biostudies-other

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In non-severe hemophilia A the risk of inhibitor after intensive factor treatment is greater in older patients: a case-control study.

Kempton C L CL Soucie J M JM Miller C H CH Hooper C C Escobar M A MA Cohen A J AJ Key N S NS Thompson A R AR Abshire T C TC

Journal of thrombosis and haemostasis : JTH 20101001 10

<h4>Background</h4> Twenty-five percent of new anti-factor VIII (FVIII) antibodies (inhibitors) that complicate hemophilia A occur in those with mild and moderate disease. Although intensive FVIII treatment has long been considered a risk factor for inhibitor development in those with non-severe disease, its strength of association and the influence of other factors have remained undefined.<h4>Objective</h4> To evaluate risk factors for inhibitor development in patients with non-severe hemophili ...[more]

PMID: 20704648

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Dataset Information

In non-severe hemophilia A the risk of inhibitor after intensive factor treatment is greater in older patients: a case-control study.

Publications

In non-severe hemophilia A the risk of inhibitor after intensive factor treatment is greater in older patients: a case-control study.

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