Unknown

Dataset Information

0

Niche-less maintenance of HSCs by 2i.


ABSTRACT: Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs) is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines, serum, or feeder cells.

SUBMITTER: Masuda S 

PROVIDER: S-EPMC3616430 | biostudies-other | 2013 Apr

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC4851409 | biostudies-literature
| S-EPMC4398368 | biostudies-literature
| S-EPMC3951515 | biostudies-literature
| S-EPMC4459580 | biostudies-literature
| S-EPMC5972425 | biostudies-literature
| S-EPMC3706621 | biostudies-literature
| S-EPMC8321521 | biostudies-literature
| S-EPMC4403793 | biostudies-literature
| S-EPMC6700448 | biostudies-literature
| S-EPMC4871447 | biostudies-literature