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Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer.


ABSTRACT: BACKGROUND: Evidence for non-steroidal anti-inflammatory drugs (NSAIDs) preventing head and neck cancer (HNC) is inconclusive; however, there is some suggestion that aspirin may exert a protective effect. METHODS: Using data from the United States National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined the association between aspirin and ibuprofen use and HNC. RESULTS: Regular aspirin use was associated with a significant 22% reduction in HNC risk. No association was observed with regular ibuprofen use. CONCLUSION: Aspirin may have potential as a chemopreventive agent for HNC, but further investigation is warranted.

SUBMITTER: Wilson JC 

PROVIDER: S-EPMC3619083 | biostudies-other | 2013 Mar

REPOSITORIES: biostudies-other

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Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer.

Wilson J C JC   Murray L J LJ   Hughes C M CM   Black A A   Anderson L A LA  

British journal of cancer 20130228 5


<h4>Background</h4>Evidence for non-steroidal anti-inflammatory drugs (NSAIDs) preventing head and neck cancer (HNC) is inconclusive; however, there is some suggestion that aspirin may exert a protective effect.<h4>Methods</h4>Using data from the United States National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined the association between aspirin and ibuprofen use and HNC.<h4>Results</h4>Regular aspirin use was associated with a significant 22% reduct  ...[more]

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