I want to lie about not knowing you, but my precuneus refuses to cooperate.
Ontology highlight
ABSTRACT:
SUBMITTER: Lee TM
PROVIDER: S-EPMC3622132 | biostudies-other | 2013
REPOSITORIES: biostudies-other
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Project description:BackgroundDeception is present in all walks of life, from social interactions to matters of homeland security. Nevertheless, reliable indicators of deceptive behavior in real-life scenarios remain elusive.MethodsBy integrating electrophysiological and communicative approaches, we demonstrate a new and objective detection approach to identify participant-specific indicators of deceptive behavior in an interactive scenario of a two-person deception task. We recorded participants' facial muscle activity using novel dry screen-printed electrode arrays and applied machine-learning algorithms to identify lies based on brief facial responses.ResultsWith an average accuracy of 73%, we identified two groups of participants: Those who revealed their lies by activating their cheek muscles and those who activated their eyebrows. We found that the participants lied more often with time, with some switching their telltale muscle groups. Moreover, while the automated classifier, reported here, outperformed untrained human detectors, their performance was correlated, suggesting reliance on shared features.ConclusionsOur findings demonstrate the feasibility of using wearable electrode arrays in detecting human lies in a social setting and set the stage for future research on individual differences in deception expression.
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Project description:Meta-analytic findings indicate that the success of unmasking a deceptive interaction relies more on the performance of the liar than on that of the lie detector. Despite this finding, the lie characteristics and strategies of deception that enable good liars to evade detection are largely unknown. We conducted a survey (n = 194) to explore the association between laypeople's self-reported ability to deceive on the one hand, and their lie prevalence, characteristics, and deception strategies in daily life on the other. Higher self-reported ratings of deception ability were positively correlated with self-reports of telling more lies per day, telling inconsequential lies, lying to colleagues and friends, and communicating lies via face-to-face interactions. We also observed that self-reported good liars highly relied on verbal strategies of deception and they most commonly reported to i) embed their lies into truthful information, ii) keep the statement clear and simple, and iii) provide a plausible account. This study provides a starting point for future research exploring the meta-cognitions and patterns of skilled liars who may be most likely to evade detection.
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Project description:Sickle cell disease (SCD) impacts millions of individuals worldwide and more than 100,000 people in the United States. Leg ulcers are the most common cutaneous manifestation of SCD. The health status of individuals living with chronic leg ulcers is not only influenced by clinical manifestations such as pain duration and intensity, but also by psychosocial factors. Garnering insights into the psychosocial impact can provide a more holistic view of their influence on quality of life.Semi-structured interviews were conducted with participants living with active SCD-associated leg ulcers or with a history of ulcers. Subjects were recruited from an ongoing study (INSIGHTS, Clin Trial.Gov NCT02156102) and consented to this qualitative phase of the study. Five areas were explored: leg ulcer pain, physical function, social-isolation, social relationships and religious support. Data was collected from 20 individuals during these interviews and a thematic analysis was performed and reported.Twenty participants with a mean age of 42.4 (SD ± 11.1years) were included in the study. Major themes identified included:1) pain (acute and chronic); 2) compromised physical function as demonstrated by decreased ability to walk, run, and play sports; 3) social isolation from activities either by others or self-induced as a means of avoiding certain emotions, such as embarrassment; 4) social relationships (family support and social network); 5) support and comfort through their religion or spirituality.SCD patients with leg ulcers expressed that they experience social isolation, intense and frequent ulcer pain, and difficulty in physical function. SCD-associated leg ulcers have been studied from a clinical approach, but the psychosocial factors investigated in this study informs how quality of life is impacted by the leg ulcers.
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Project description:BackgroundTransgender individuals are less likely to have had a primary care visit in the last year than cisgender individuals. While the importance of multidisciplinary clinics for transgender care has been established, little is known about the healthcare experiences of transgender patients with these clinics.ObjectiveTo describe how patients experience transgender clinics and how these experiences compare to those experiences in other settings.ParticipantsTwenty-one adult patients of a gender health program.Design and approachSemi-structured interviews of transgender patients. The interviews focused on two domains: healthcare experiences and relationships with healthcare providers.Key resultsOverall, transgender patients expressed a need for healthcare services, particularly for primary care, that are partially met by the comprehensive care clinic model. Limitations in access included the lack of willing providers, where the patients live, and long wait times for appointments. Participants recounted a range of experiences, both positive and negative, with providers outside of the transgender clinic, but only positive experiences to share about providers from the transgender clinic.ConclusionOutside specialty transgender settings, many patients had negative experiences with providers who were unwilling or unable to provide care. This study speaks to the need for primary care providers who can and will treat transgender patients, as well as the need for healthcare spaces that feel safe to transgender patents.
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Project description:Bacterial signal transduction systems are responsible for sensing environmental cues and adjusting the cellular behaviour and/or metabolism in response to these cues. They also monitor the intracellular conditions and the status of the cell envelope and the cytoplasmic membrane and trigger various stress responses to counteract adverse changes. This surveillance involves several classes of sensor proteins: histidine kinases; chemoreceptors; membrane components of the sugar phosphotransferase system; adenylate, diadenylate and diguanylate cyclases and certain cAMP, c-di-AMP and c-di-GMP phosphodiesterases; extracytoplasmic function sigma factors and Ser/Thr/Tyr protein kinases and phosphoprotein phosphatases. We have compiled a detailed listing of sensor proteins that are encoded in the genomes of Escherichia coli, Bacillus subtilis and 10 widespread pathogens: Chlamydia trachomatis, Haemophilus influenzae, Helicobacter pylori, Mycobacterium tuberculosis, Mycoplasma pneumoniae, Neisseria gonorrhoeae, Porphyromonas gingivalis, Rickettsia typhi, Streptococcus pyogenes and Treponema pallidum, and checked what, if anything, is known about their functions. This listing shows significant gaps in the understanding of which environmental and intracellular cues are perceived by these bacteria and which cellular responses are triggered by the changes in the respective parameters. A better understanding of bacterial preferences may suggest new ways to modulate the expression of virulence factors and therefore decrease the reliance on antibiotics to fight infection.
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