Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.
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ABSTRACT:
SUBMITTER: Drivas GT
PROVIDER: S-EPMC362288 | biostudies-other | 1990 Apr
REPOSITORIES: biostudies-other
Publications
Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.
Drivas G T GT Shih A A Coutavas E E Rush M G MG D'Eustachio P P
Molecular and cellular biology 19900401 4
A mixed-oligonucleotide probe was used to identify four ras-like coding sequences in a human teratocarcinoma cDNA library. Two of these sequences resembled the rho genes, one was closely related to H-, K-, and N-ras, and one shared only the four sequence domains that define the ras gene superfamily. Homologs of the four genes were found in genomic DNA from a variety of mammals and from chicken. The genes were transcriptionally active in a range of human cell types. ...[more]
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