Ontology highlight
ABSTRACT:
SUBMITTER: Fregoso OI
PROVIDER: S-EPMC3628402 | biostudies-other | 2013 Apr
REPOSITORIES: biostudies-other
Fregoso Oliver I OI Das Shipra S Akerman Martin M Krainer Adrian R AR
Molecular cell 20130307 1
Splicing and translation are highly regulated steps of gene expression. Altered expression of proteins involved in these processes can be deleterious. Therefore, the cell has many safeguards against such misregulation. We report that the oncogenic splicing factor SRSF1, which is overexpressed in many cancers, stabilizes the tumor suppressor protein p53 by abrogating its MDM2-dependent proteasomal degradation. We show that SRSF1 is a necessary component of an MDM2/ribosomal protein complex, separ ...[more]