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Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells.

ABSTRACT: We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of migrating cells (usually within 0.5 ?m of polymerized actin and close to focal adhesions) and appeared suddenly without sliding from the interior of the cell. The long distance sliding and dissolution of ER-PM junctions accompanied the tail withdrawal.

SUBMITTER: Dingsdale H

PROVIDER: S-EPMC3632088 | biostudies-other | 2013 Apr

REPOSITORIES: biostudies-other

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Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells.

Dingsdale Hayley H Okeke Emmanuel E Awais Muhammad M Haynes Lee L Criddle David N DN Sutton Robert R Tepikin Alexei V AV

The Biochemical journal 20130401 1

We demonstrated three novel forms of dynamic behaviour of junctions between the ER (endoplasmic reticulum) and the PM (plasma membrane) in migrating cancer cells: saltatory formation, long-distance sliding and dissolution. The individual ER-PM junctions formed near the leading edge of migrating cells (usually within 0.5 μm of polymerized actin and close to focal adhesions) and appeared suddenly without sliding from the interior of the cell. The long distance sliding and dissolution of ER-PM junc ...[more]

PMID: 23323887

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