Ontology highlight
ABSTRACT:
SUBMITTER: Dai X
PROVIDER: S-EPMC3638909 | biostudies-other | 2013 May
REPOSITORIES: biostudies-other
Dai Xuezhi X James Richard G RG Habib Tania T Singh Swati S Jackson Shaun S Khim Socheath S Moon Randall T RT Liggitt Denny D Wolf-Yadlin Alejandro A Buckner Jane H JH Rawlings David J DJ
The Journal of clinical investigation 20130424 5
Multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, Graves disease, and systemic lupus erythematosus, are associated with an allelic variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22), which encodes the protein LYP. To model the human disease-linked variant LYP-R620W, we generated knockin mice expressing the analogous mutation, R619W, in the murine ortholog PEST domain phosphatase (PEP). In contrast with a previous report, we found that this variant exhibi ...[more]