Ontology highlight
ABSTRACT:
SUBMITTER: Desforges B
PROVIDER: S-EPMC3655814 | biostudies-other | 2013 May
REPOSITORIES: biostudies-other
Desforges Bénédicte B Curmi Patrick A PA Bounedjah Ouissame O Nakib Samir S Hamon Loic L De Bandt Jean-Pascal JP Pastré David D
Molecular biology of the cell 20130320 10
In the organism, quiescent epithelial cells have the potential to resume cycling as a result of various stimuli, including wound healing or oxidative stress. Because quiescent cells have a low polyamine level, resuming their growth requires an increase of their intracellular polyamine levels via de novo polyamine synthesis or their uptake from plasma. Another alternative, explored here, is an intercellular exchange with polyamine-rich cycling cells via gap junctions. We show that polyamines prom ...[more]