Tobacco smoking leads to extensive genome-wide changes in DNA methylation.
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ABSTRACT:
SUBMITTER: Zeilinger S
PROVIDER: S-EPMC3656907 | biostudies-other | 2013
REPOSITORIES: biostudies-other
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Tobacco smoking leads to extensive genome-wide changes in DNA methylation.
Zeilinger Sonja S Kühnel Brigitte B Klopp Norman N Baurecht Hansjörg H Kleinschmidt Anja A Gieger Christian C Weidinger Stephan S Lattka Eva E Adamski Jerzy J Peters Annette A Strauch Konstantin K Waldenberger Melanie M Illig Thomas T
PloS one 20130517 5
Environmental factors such as tobacco smoking may have long-lasting effects on DNA methylation patterns, which might lead to changes in gene expression and in a broader context to the development or progression of various diseases. We conducted an epigenome-wide association study (EWAs) comparing current, former and never smokers from 1793 participants of the population-based KORA F4 panel, with replication in 479 participants from the KORA F3 panel, carried out by the 450K BeadChip with genomic ...[more]
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