Perspectives on treatment of metastatic castration-resistant prostate cancer.
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ABSTRACT:
SUBMITTER: Merseburger AS
PROVIDER: S-EPMC3662847 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Publications
Perspectives on treatment of metastatic castration-resistant prostate cancer.
Merseburger Axel S AS Bellmunt Joaquim J Jenkins Cheryl C Parker Chris C Fitzpatrick John M JM
The oncologist 20130513 5
The arrival of several new agents--cabazitaxel, abiraterone acetate, enzalutamide, and radium-223--is changing the treatment options and management of patients with metastatic castration-resistant prostate cancer (mCRPC). Many other novel agents are also being investigated. As new drugs become approved, new treatment strategies and markers to best select which patients will best respond to which drug are needed. This review article is a summary of a European Treatment Practices Meeting, which wa ...[more]
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Project description:The management of men with metastatic castration-resistant prostate cancer (CRPC) has taken several leaps forward in the last 2 years, with the demonstration of improved overall survival with three novel agents (sipuleucel-T, cabazitaxel, and abiraterone acetate), and a significant delay in skeletal-related events observed with denosumab. The pipeline of systemic therapies in prostate cancer remains strong, as multiple agents with a diverse array of mechanisms of action are demonstrating preliminary signs of clinical benefit, leading to more definitive phase III confirmatory trials. In this review, we will discuss the evolving landscape of treatment options for men with CRPC, with a particular focus on currently approved and emerging treatment options for these patients. Knowledge of these evolving standards will help to optimize delivery of care and long term outcomes in men with advanced CRPC.
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