Ontology highlight
ABSTRACT:
SUBMITTER: Qu Y
PROVIDER: S-EPMC3664827 | biostudies-other | 2013 May
REPOSITORIES: biostudies-other
Nucleic acids research 20130410 10
Bacterial nucleoid-associated proteins, such as H-NS-like proteins in Enterobacteriaceae, are abundant DNA-binding proteins that function in chromosomal DNA organization and gene transcription regulation. The Mycobacterium tuberculosis Lsr2 protein has been proposed to be the first identified H-NS analogue in Gram-positive bacteria based on its capability to complement numerous in vivo functions of H-NS. Here, we report that Lsr2 cooperatively binds to DNA forming a rigid Lsr2 nucleoprotein comp ...[more]