Ontology highlight
ABSTRACT:
SUBMITTER: Stoltz DA
PROVIDER: S-EPMC3668832 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
Stoltz David A DA Rokhlina Tatiana T Ernst Sarah E SE Pezzulo Alejandro A AA Ostedgaard Lynda S LS Karp Philip H PH Samuel Melissa S MS Reznikov Leah R LR Rector Michael V MV Gansemer Nicholas D ND Bouzek Drake C DC Abou Alaiwa Mahmoud H MH Hoegger Mark J MJ Ludwig Paula S PS Taft Peter J PJ Wallen Tanner J TJ Wohlford-Lenane Christine C McMenimen James D JD Chen Jeng-Haur JH Bogan Katrina L KL Adam Ryan J RJ Hornick Emma E EE Nelson George A GA Hoffman Eric A EA Chang Eugene H EH Zabner Joseph J McCray Paul B PB Prather Randall S RS Meyerholz David K DK Welsh Michael J MJ
The Journal of clinical investigation 20130508 6
Cystic fibrosis (CF) pigs develop disease with features remarkably similar to those in people with CF, including exocrine pancreatic destruction, focal biliary cirrhosis, micro-gallbladder, vas deferens loss, airway disease, and meconium ileus. Whereas meconium ileus occurs in 15% of babies with CF, the penetrance is 100% in newborn CF pigs. We hypothesized that transgenic expression of porcine CF transmembrane conductance regulator (pCFTR) cDNA under control of the intestinal fatty acid-binding ...[more]