Ontology highlight
ABSTRACT:
SUBMITTER: Nagashima T
PROVIDER: S-EPMC3668851 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
Nagashima Takashi T Li Qinglei Q Clementi Caterina C Lydon John P JP DeMayo Francesco J FJ Matzuk Martin M MM
The Journal of clinical investigation 20130508 6
Abnormalities in cell-cell communication and growth factor signaling pathways can lead to defects in maternal-fetal interactions during pregnancy, including immunologic rejection of the fetal/placental unit. In this study, we discovered that bone morphogenetic protein receptor type 2 (BMPR2) is essential for postimplantation physiology and fertility. Despite normal implantation and early placental/fetal development, deletion of Bmpr2 in the uterine deciduae of mice triggered midgestation abnorma ...[more]