The FBW7-KLF2 axis regulates endothelial functions.

ABSTRACT: FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study in this issue of Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC3674388 | biostudies-other | 2013 Jun

REPOSITORIES: biostudies-other