A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.
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ABSTRACT:
SUBMITTER: Schachter MM
PROVIDER: S-EPMC3677717 | biostudies-other | 2013 Apr
REPOSITORIES: biostudies-other
Publications
A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.
Schachter Miriam Merzel MM Merrick Karl A KA Larochelle Stéphane S Hirschi Alexander A Zhang Chao C Shokat Kevan M KM Rubin Seth M SM Fisher Robert P RP
Molecular cell 20130401 2
Eukaryotic cell division is controlled by cyclin-dependent kinases (CDKs), which require phosphorylation by a CDK-activating kinase (CAK) for full activity. Chemical genetics uncovered requirements for the metazoan CAK Cdk7 in determining cyclin specificity and activation order of Cdk2 and Cdk1 during S and G2 phases. It was unknown if Cdk7 also activates Cdk4 and Cdk6 to promote passage of the restriction (R) point, when continued cell-cycle progression becomes mitogen independent, or if CDK-ac ...[more]
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