Ontology highlight
ABSTRACT:
SUBMITTER: Schachter MM
PROVIDER: S-EPMC3677717 | biostudies-other | 2013 Apr
REPOSITORIES: biostudies-other
Molecular cell 20130401 2
Eukaryotic cell division is controlled by cyclin-dependent kinases (CDKs), which require phosphorylation by a CDK-activating kinase (CAK) for full activity. Chemical genetics uncovered requirements for the metazoan CAK Cdk7 in determining cyclin specificity and activation order of Cdk2 and Cdk1 during S and G2 phases. It was unknown if Cdk7 also activates Cdk4 and Cdk6 to promote passage of the restriction (R) point, when continued cell-cycle progression becomes mitogen independent, or if CDK-ac ...[more]