Ontology highlight
ABSTRACT:
SUBMITTER: Yuan J
PROVIDER: S-EPMC3696823 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20130610 26
The RAD51 recombinase plays a central role in homologous recombination (HR), which is critical for repair of DNA double-strand breaks, maintenance of genomic stability, and prevention of developmental disorders and cancer. Here, we report the identification of an RAD51-binding protein fidgetin-like 1 (FIGNL1). FIGNL1 specifically interacts with RAD51 through its conserved RAD51 binding domain. Cells depleted of FIGNL1 show defective HR repair. Interestingly, FIGNL1 is recruited to sites of DNA d ...[more]