Ontology highlight
ABSTRACT:
SUBMITTER: Kerkela E
PROVIDER: S-EPMC3697819 | biostudies-other | 2013 Jul
REPOSITORIES: biostudies-other
Kerkelä Erja E Hakkarainen Tanja T Mäkelä Tuomas T Raki Mari M Kambur Oleg O Kilpinen Lotta L Nikkilä Janne J Lehtonen Siri S Ritamo Ilja I Pernu Roni R Pietilä Mika M Takalo Reijo R Juvonen Tatu T Bergström Kim K Kalso Eija E Valmu Leena L Laitinen Saara S Lehenkari Petri P Nystedt Johanna J
Stem cells translational medicine 20130603 7
Systemic infusion of therapeutic cells would be the most practical and least invasive method of administration in many cellular therapies. One of the main obstacles especially in intravenous delivery of cells is a massive cell retention in the lungs, which impairs homing to the target tissue and may decrease the therapeutic outcome. In this study we showed that an alternative cell detachment of mesenchymal stromal/stem cells (MSCs) with pronase instead of trypsin significantly accelerated the lu ...[more]