Unknown

Dataset Information

0

A novel onco-miR-365 induces cutaneous squamous cell carcinoma.


ABSTRACT: The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in vivo. Antagomir-365, an anti-miR-365 oligonucleotide, inhibited cutaneous tumor formation in vivo, along with G1 phase arrest and apoptosis of cancer cells. These findings suggest that miR-365 may act as an onco-miR in cutaneous SCC both in vitro and in vivo. The present study provides valuable insight into the role of miR-365 in cutaneous SCC formation, which can help develop new drug and miR-365 target-based therapies for cutaneous SCC.

SUBMITTER: Zhou M 

PROVIDER: S-EPMC3697891 | biostudies-other | 2013 Jul

REPOSITORIES: biostudies-other

altmetric image

Publications


The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in vivo. Antagomir-365, an anti-miR-365 oligonucleotide, inhibited cutaneous tumor formation in vivo, along with G1 phase arrest and apoptosis of cancer cells. These findings suggest that  ...[more]

Similar Datasets

| S-EPMC4960761 | biostudies-literature
| S-EPMC6985147 | biostudies-literature
| S-EPMC3703599 | biostudies-literature
| S-EPMC5607211 | biostudies-other
| S-EPMC4130727 | biostudies-literature
| S-EPMC5466895 | biostudies-literature
| S-EPMC11367778 | biostudies-literature
| S-EPMC8998533 | biostudies-literature
| S-EPMC6678994 | biostudies-literature
| S-EPMC4065106 | biostudies-literature