Ontology highlight
ABSTRACT:
SUBMITTER: Zhou M
PROVIDER: S-EPMC3697891 | biostudies-other | 2013 Jul
REPOSITORIES: biostudies-other
Carcinogenesis 20130320 7
The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in vivo. Antagomir-365, an anti-miR-365 oligonucleotide, inhibited cutaneous tumor formation in vivo, along with G1 phase arrest and apoptosis of cancer cells. These findings suggest that ...[more]