Ontology highlight
ABSTRACT:
SUBMITTER: Radkevich-Brown O
PROVIDER: S-EPMC3702174 | biostudies-other | 2010 Mar
REPOSITORIES: biostudies-other
Radkevich-Brown Olga O Piechocki Marie P MP Back Jessica B JB Weise Amy M AM Pilon-Thomas Shari S Wei Wei-Zen WZ
Cancer immunology, immunotherapy : CII 20100301 3
In situ expression of a foreign antigen and an immune-modulating cytokine by intratumoral DNA electroporation was tested as a cancer therapy regimen. Transgene expression in the tumors was sustained for 2-3 weeks after intratumoral electroporation with mammalian expression plasmid containing firefly luciferase cDNA. Electroporation with cDNA encoding tetanus toxin fragment C (TetC) induced tetanus toxin-binding antibody, demonstrating immune recognition of the transgene product. Intratumoral ele ...[more]