Science to practice: Can we expand focal interventional oncologic ablation treatments into an effective systemic therapy?

ABSTRACT: Hamamoto et al (1) were able to demonstrate that combination therapy of a lung tumor by using radiofrequency ablation (RFA) with local injection of an immunostimulant, OK-432, resulted in improved survival when compared with other therapies tested in a VX2 rabbit model. In addition, not only was greater tumor regression seen in a second distant ear tumor implanted prior to the therapy, but also reduced tumor growth was seen when a second tumor implantation (ie, rechallenge) was attempted. These factors strongly suggest the successful activation of systemic antitumor immunity using this approach in this specific tumor model.

SUBMITTER: Goldberg SN 

PROVIDER: S-EPMC3709510 | biostudies-other | 2013 May

REPOSITORIES: biostudies-other