Ontology highlight
ABSTRACT:
SUBMITTER: Puglisi EV
PROVIDER: S-EPMC3710119 | biostudies-other | 2011 Jul
REPOSITORIES: biostudies-other
Puglisi Elisabetta Viani EV Puglisi Joseph D JD
Journal of molecular biology 20110701 5
Initiation of reverse transcription of genomic RNA is a key early step in replication of the human immunodeficiency virus (HIV) upon infection of a host cell. Viral reverse transcriptase initiates from a specific RNA-RNA complex formed between a host transfer RNA (tRNA(Lys)(3)) and a region at the 5' end of genomic RNA; the 3' end of the tRNA acts as a primer for reverse transcription of genomic RNA. We report here the secondary structure of the HIV genomic RNA-human tRNA(Lys)(3) initiation comp ...[more]