Ontology highlight
ABSTRACT:
SUBMITTER: McDougle DR
PROVIDER: S-EPMC3719090 | biostudies-other | 2013 Jul
REPOSITORIES: biostudies-other
McDougle Daniel R DR Palaria Amrita A Magnetta Eric E Meling Daryl D DD Das Aditi A
Protein science : a publication of the Protein Society 20130701 7
CYP2J2 epoxygenase is a membrane bound cytochrome P450 that converts omega-3 and omega-6 fatty acids into physiologically active epoxides. In this work, we present a comprehensive comparison of the effects of N-terminal modifications on the properties of CYP2J2 with respect to the activity of the protein in model lipid bilayers using Nanodiscs. We demonstrate that the complete truncation of the N-terminus changes the association of this protein with the E.coli membrane but does not disrupt incor ...[more]