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Influence of initial treatment modality on long-term control of chronic idiopathic urticaria.


ABSTRACT: BACKGROUND: Chronic idiopathic urticaria (CIU) is a common cutaneous disorder but the influence of initial treatment modality on long-term control is not known. The aim of this study was to evaluate clinical features, and the influence of initial treatment modality on long-term control. METHODS AND RESULTS: 641 CIU patients were enrolled from the allergy clinic in a tertiary referral hospital. Disease duration, aggravating factors and treatment modality at each visit were evaluated. Times required to reach a controlled state were analyzed according to initial treatment modality, using Kaplan-Meier survival curves, the Cox proportional-hazards model, and propensity scores. Female to male ratio was 1.7: 1; mean age at onset was 40.5 years. The most common aggravating factors were food (33.5%), stress (31.5%) and fatigue (21.6%). Most patients (82.2%) used H1-antihistamines alone as initial treatment while 17% used a combination treatment with oral corticosteroids. There was no significant difference in the time taken to reach a controlled state between patients treated with single vs multiple H1-antihistamines or between those who received H1-antihistamine monotherapy vs. a combination therapy with oral corticosteroids. CONCLUSION: The time required to control CIU is not reduced by use of multiple H1-antihistamines or oral corticosteroids in the initial treatment.

SUBMITTER: Kim S 

PROVIDER: S-EPMC3720657 | biostudies-other | 2013

REPOSITORIES: biostudies-other

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Influence of initial treatment modality on long-term control of chronic idiopathic urticaria.

Kim Sujeong S   Baek Seunghee S   Shin Bomi B   Yoon Sun-young SY   Park So Young SY   Lee Taehoon T   Lee Yoon Su YS   Bae Yun-Jeong YJ   Kwon Hyouk Soo HS   Cho You Sook YS   Moon Hee-Bom HB   Kim Tae-Bum TB  

PloS one 20130723 7


<h4>Background</h4>Chronic idiopathic urticaria (CIU) is a common cutaneous disorder but the influence of initial treatment modality on long-term control is not known. The aim of this study was to evaluate clinical features, and the influence of initial treatment modality on long-term control.<h4>Methods and results</h4>641 CIU patients were enrolled from the allergy clinic in a tertiary referral hospital. Disease duration, aggravating factors and treatment modality at each visit were evaluated.  ...[more]

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