Ontology highlight
ABSTRACT:
SUBMITTER: Griewank KG
PROVIDER: S-EPMC3721405 | biostudies-other | 2013 Jul
REPOSITORIES: biostudies-other
Griewank K G KG Murali R R Schilling B B Scholz S S Sucker A A Song M M Süsskind D D Grabellus F F Zimmer L L Hillen U U Steuhl K-P KP Schadendorf D D Westekemper H H Zeschnigk M M
British journal of cancer 20130625 2
<h4>Background</h4>Recently, activating mutations in the TERT promoter were identified in cutaneous melanoma. We tested a cohort of ocular melanoma samples for similar mutations.<h4>Methods</h4>The TERT promoter region was analysed by Sanger sequencing in 47 uveal (ciliary body or choroidal) melanomas and 38 conjunctival melanomas.<h4>Results</h4>Mutations of the TERT promoter were not identified in uveal melanomas, but were detected in 12 (32%) conjunctival melanomas. Mutations had a UV signatu ...[more]