Ontology highlight
ABSTRACT:
SUBMITTER: Albertazzi L
PROVIDER: S-EPMC3725081 | biostudies-other | 2013 Jul
REPOSITORIES: biostudies-other
Albertazzi Lorenzo L Martinez-Veracoechea Francisco J FJ Leenders Christianus M A CM Voets Ilja K IK Frenkel Daan D Meijer E W EW
Proceedings of the National Academy of Sciences of the United States of America 20130708 30
Multivalency has an important but poorly understood role in molecular self-organization. We present the noncovalent synthesis of a multicomponent supramolecular polymer in which chemically distinct monomers spontaneously coassemble into a dynamic, functional structure. We show that a multivalent recruiter is able to bind selectively to one subset of monomers (receptors) and trigger their clustering along the self-assembled polymer, behavior that mimics raft formation in cell membranes. This phen ...[more]