Ontology highlight
ABSTRACT:
SUBMITTER: Cook RS
PROVIDER: S-EPMC3726162 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Cook Rebecca S RS Jacobsen Kristen M KM Wofford Anne M AM DeRyckere Deborah D Stanford Jamie J Prieto Anne L AL Redente Elizabeth E Sandahl Melissa M Hunter Debra M DM Strunk Karen E KE Graham Douglas K DK Earp H Shelton HS
The Journal of clinical investigation 20130708 8
MerTK, a receptor tyrosine kinase (RTK) of the TYRO3/AXL/MerTK family, is expressed in myeloid lineage cells in which it acts to suppress proinflammatory cytokines following ingestion of apoptotic material. Using syngeneic mouse models of breast cancer, melanoma, and colon cancer, we found that tumors grew slowly and were poorly metastatic in MerTK-/- mice. Transplantation of MerTK-/- bone marrow, but not wild-type bone marrow, into lethally irradiated MMTV-PyVmT mice (a model of metastatic brea ...[more]