Ontology highlight
ABSTRACT:
SUBMITTER: Minvielle MJ
PROVIDER: S-EPMC3733276 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
Minvielle Marine J MJ Bunders Cynthia A CA Melander Christian C
MedChemComm 20130601 6
Herein is described a method of accessing indole/triazole and benzothiophene/triazole analogues that selectively promote or inhibit biofilm formation by Gram-positive and Gram-negative bacteria. Structure/function studies revealed that the addition of a bromine atom at the 2-position of the indole/triazole scaffold altered activity against both Gram-negative and Gram-positive bacteria and could transform a biofilm inhibitor into a biofilm inducer. Isosteric replacement of the indole core by a be ...[more]