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Pulse radiolysis studies on the reaction of the reduced vitamin B?? complex Cob(II)alamin with superoxide.

ABSTRACT: O?.- scavenger: The rate constant for the rapid reaction of the ROS superoxide with the reduced vitamin B?? radical complex cob(II)alamin was directly determined to be 3.8×10(8) M?¹ s?¹. This rate was independent of pH over the range 5.5-8.7. These results have implications for studying the use of B?? supplements to combat diseases associated with oxidative stress.

SUBMITTER: Dassanayake RS

PROVIDER: S-EPMC3737425 | biostudies-other | 2013 Jun

REPOSITORIES: biostudies-other

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Pulse radiolysis studies on the reaction of the reduced vitamin B₁₂ complex Cob(II)alamin with superoxide.

Dassanayake Rohan S RS Cabelli Diane E DE Brasch Nicola E NE

Chembiochem : a European journal of chemical biology 20130513 9

O₂.- scavenger: The rate constant for the rapid reaction of the ROS superoxide with the reduced vitamin B₁₂ radical complex cob(II)alamin was directly determined to be 3.8×10(8) M⁻¹ s⁻¹. This rate was independent of pH over the range 5.5-8.7. These results have implications for studying the use of B₁₂ supplements to combat diseases associated with oxidative stress. ...[more]

PMID: 23671003

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