Ontology highlight
ABSTRACT:
SUBMITTER: Alabi CA
PROVIDER: S-EPMC3740846 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Alabi Christopher A CA Love Kevin T KT Sahay Gaurav G Yin Hao H Luly Kathryn M KM Langer Robert R Anderson Daniel G DG
Proceedings of the National Academy of Sciences of the United States of America 20130723 32
Nanoparticle-mediated siRNA delivery is a complex process that requires transport across numerous extracellular and intracellular barriers. As such, the development of nanoparticles for efficient delivery would benefit from an understanding of how parameters associated with these barriers relate to the physicochemical properties of nanoparticles. Here, we use a multiparametric approach for the evaluation of lipid nanoparticles (LNPs) to identify relationships between structure, biological functi ...[more]