Ontology highlight
ABSTRACT:
SUBMITTER: Ding T
PROVIDER: S-EPMC3741385 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Ding Ting T Zhou Ying Y Sun Kai K Jiang Weizhong W Li Wenliang W Liu Xiaoli X Tian Chunying C Li Zhihui Z Ying Guoguang G Fu Li L Gu Feng F Li Weidong W Ma Yongjie Y
PloS one 20130812 8
Glioblastomas are the most aggressive forms of primary brain tumors due to their tendency to invade surrounding healthy brain tissues, rendering them largely incurable. The water channel protein, Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis in the central nervous system and has recently been reported with cell survival except for its well-known function in brain edema. An increased AQP4 expression has been demonstrated in glioblastoma multiforme (GBM), suggestin ...[more]