Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC3741624 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Li Bojun B Moshfegh Cameron C Lin Zhe Z Albuschies Jörg J Vogel Viola V
Scientific reports 20130101
While stem cells can sense and respond to physical properties of their environment, the molecular aspects how physical information is translated into biochemical signals remain unknown. Here we show that human mesenchymal stem cells (hMSCs) harvest and assemble plasma fibronectin into their extracellular matrix (ECM) fibrils within 24 hours. hMSCs pro-actively pull on newly assembled fibronectin ECM fibrils, and the fibers are more stretched on rigid than on soft fibronectin-coated polyacrylamid ...[more]