Statistical analysis strategies for association studies involving rare variants.
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ABSTRACT:
SUBMITTER: Bansal V
PROVIDER: S-EPMC3743540 | biostudies-other | 2010 Nov
REPOSITORIES: biostudies-other
Publications
Statistical analysis strategies for association studies involving rare variants.
Bansal Vikas V Libiger Ondrej O Torkamani Ali A Schork Nicholas J NJ
Nature reviews. Genetics 20101013 11
The limitations of genome-wide association (GWA) studies that focus on the phenotypic influence of common genetic variants have motivated human geneticists to consider the contribution of rare variants to phenotypic expression. The increasing availability of high-throughput sequencing technologies has enabled studies of rare variants but these methods will not be sufficient for their success as appropriate analytical methods are also needed. We consider data analysis approaches to testing associ ...[more]
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