Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC3746205 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Scientific reports 20130101
Two mixed-NH3/amine platinum (II) complexes of 3-dichoroacetoxylcyclobutane-1, 1-dicarboxylate have been prepared in the present study and characterized by elemental analysis and IR, HPLC-MS and (1)H, (13)C-NMR. The complexes exist in equilibrium between two position isomeric forms and undergo hydrolysis reaction in aqueous solution, releasing the platinum pharmacophores and dichloroacetate which is a small-molecular cell apoptosis inducer. Both complexes were evaluated for in vitro cytotoxic pr ...[more]