Ontology highlight
ABSTRACT:
SUBMITTER: Hill DN
PROVIDER: S-EPMC3746846 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Hill Daniel N DN Varga Zsuzsanna Z Jia Hongbo H Sakmann Bert B Konnerth Arthur A
Proceedings of the National Academy of Sciences of the United States of America 20130731 33
Layer 5 pyramidal neurons process information from multiple cortical layers to provide a major output of cortex. Because of technical limitations it has remained unclear how these cells integrate widespread synaptic inputs located in distantly separated basal and tuft dendrites. Here, we obtained in vivo two-photon calcium imaging recordings from the entire dendritic field of layer 5 motor cortex neurons. We demonstrate that during subthreshold activity, basal and tuft dendrites exhibit spatiall ...[more]