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Evaluation of an empiric risk screening score to identify acute and early HIV-1 infection among MSM in Coastal Kenya.


ABSTRACT: We evaluated the University of North Carolina-Malawi Risk Screening Score (UMRSS) for detection of acute and early HIV-1 infection (AEHI) in a cohort of Kenyan MSM with approximately 8% annual HIV-1 incidence. Three components of the UMRSS (fever, diarrhea, and discordant rapid HIV tests) were also independent predictors of AEHI in our cohort. The predictive ability (area under the receiver operating characteristic curve, AUC) of the UMRSS was 0.79. A cohort-derived risk score consisting of six characteristics (fever, diarrhea, discordant rapid HIV tests, fatigue, age <30 years, and symptomatic sexually transmitted disease) had a higher AUC of 0.85. Screening for AEHI will have substantial transmission prevention benefits.

SUBMITTER: Wahome E 

PROVIDER: S-EPMC3748854 | biostudies-other | 2013 Aug

REPOSITORIES: biostudies-other

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Evaluation of an empiric risk screening score to identify acute and early HIV-1 infection among MSM in Coastal Kenya.

Wahome Elizabeth E   Fegan Greg G   Okuku Haile S HS   Mugo Peter P   Price Matthew A MA   Mwashigadi Grace G   Thiong'o Alexander A   Graham Susan M SM   Sanders Eduard J EJ  

AIDS (London, England) 20130801 13


We evaluated the University of North Carolina-Malawi Risk Screening Score (UMRSS) for detection of acute and early HIV-1 infection (AEHI) in a cohort of Kenyan MSM with approximately 8% annual HIV-1 incidence. Three components of the UMRSS (fever, diarrhea, and discordant rapid HIV tests) were also independent predictors of AEHI in our cohort. The predictive ability (area under the receiver operating characteristic curve, AUC) of the UMRSS was 0.79. A cohort-derived risk score consisting of six  ...[more]

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