Ontology highlight
ABSTRACT:
SUBMITTER: Kocerha J
PROVIDER: S-EPMC3751855 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Kocerha Jannet J Liu Yuhong Y Willoughby David D Chidamparam Kumaravel K Benito Joseph J Nelson Kate K Xu Yan Y Chi Tim T Engelhardt Heidi H Moran Sean S Yang Shang-Hsun SH Li Shi-Hua SH Li Xiao-Jiang XJ Larkin Katherine K Neumann Adam A Banta Heather H Yang Jin Jing JJ Chan Anthony W S AW
BMC neuroscience 20130817
<h4>Background</h4>Huntington's Disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the polyglutamine (polyQ) region of the Huntingtin (HTT) gene. The clinical features of HD are characterized by cognitive, psychological, and motor deficits. Molecular instability, a core component in neurological disease progression, can be comprehensively evaluated through longitudinal transcriptomic profiling. Development of animal models amenable to longitudinal examination enab ...[more]