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Model selection in measures of vascular parameters using dynamic contrast-enhanced MRI: experimental and clinical applications.


ABSTRACT: A review of the selection of models in dynamic contrast-enhanced MRI (DCE-MRI) is conducted, with emphasis on the balance between the bias and variance required to produce stable and accurate estimates of vascular parameters. The vascular parameters considered as a first-order model are the forward volume transfer constant K(trans) , the plasma volume fraction vp and the interstitial volume fraction ve . To illustrate the critical issues in model selection, a data-driven selection of models in an animal model of cerebral glioma is followed. Systematic errors and extended models are considered. Studies with nested and non-nested pharmacokinetic models are reviewed; models considering water exchange are considered.

SUBMITTER: Ewing JR 

PROVIDER: S-EPMC3752406 | biostudies-other | 2013 Aug

REPOSITORIES: biostudies-other

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