Ontology highlight
ABSTRACT:
SUBMITTER: Hastie E
PROVIDER: S-EPMC3754007 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
Hastie Eric E Besmer Dahlia M DM Shah Nirav R NR Murphy Andrea M AM Moerdyk-Schauwecker Megan M Molestina Carlos C Roy Lopamudra Das LD Curry Jennifer M JM Mukherjee Pinku P Grdzelishvili Valery Z VZ
Journal of virology 20130717 18
Vesicular stomatitis virus (VSV) is a promising oncolytic agent against various malignancies. Here, for the first time, we tested VSV in vitro and in vivo in a clinically relevant, immunocompetent mouse model of pancreatic ductal adenocarcinoma (PDA). Our system allows the study of virotherapy against PDA in the context of overexpression (80% of PDA patients) or no expression of human mucin 1 (MUC1), a major marker for poor prognosis in patients. In vitro, we tested three VSV recombinants, wild- ...[more]