Ontology highlight
ABSTRACT:
SUBMITTER: Guy-Grand D
PROVIDER: S-EPMC3754871 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Guy-Grand Delphine D Vassalli Pierre P Eberl Gerard G Pereira Pablo P Burlen-Defranoux Odile O Lemaitre Fabrice F Di Santo James P JP Freitas Antonio A AA Cumano Ana A Bandeira Antonio A
The Journal of experimental medicine 20130805 9
The small intestine epithelium (SI-Ep) harbors millions of unconventional (γδ and CD4(-) CD8(-) NK1.1(-) TCRαβ) and conventional (CD8αβ and CD4) T cells, designated intraepithelial lymphocytes (IELs). Here, we identified the circulating pool of SI-Ep-tropic T cells and studied their capacity to colonize the SI-Ep under steady-state conditions in SPF mice. Developmentally regulated levels of α4β7 endowed recent thymic emigrants (RTEs) of unconventional types with higher SI-Ep tropism than their c ...[more]