Ontology highlight
ABSTRACT:
SUBMITTER: Yen BL
PROVIDER: S-EPMC3757753 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Yen B Linju BL Yen Men-Luh ML Hsu Pei-Ju PJ Liu Ko-Jiunn KJ Wang Chia-Jen CJ Bai Chyi-Huey CH Sytwu Huey-Kang HK
Stem cell reports 20130725 2
Mesenchymal stromal cells (MSCs) are multilineage progenitors with immunomodulatory properties, including expansion of immunomodulatory leukocytes such as regulatory T lymphocytes (Tregs) and tolerogenic dendritic cells. We report that human MSCs can expand CD14(-)CD11b(+)CD33(+) human myeloid-derived suppressor cells (MDSCs). MSC-expanded MDSCs suppress allogeneic lymphocyte proliferation, express arginase-1 and inducible nitric oxide synthase, and increase the number of Tregs. This expansion o ...[more]