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Building unique bonds to fight misplaced DNA.


ABSTRACT: A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the structure of the enzyme involved in the synthesis of this second messenger and identifies this cyclic dinucleotide as a unique compound in metazoan cell signaling.

SUBMITTER: Fagundes CT 

PROVIDER: S-EPMC3760622 | biostudies-other | 2013 Sep

REPOSITORIES: biostudies-other

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