Photoassisted synthesis of enantiopure alkaloid mimics possessing unprecedented polyheterocyclic cores.

ABSTRACT: Enantiopure alkaloid mimics are synthesized via high yielding intramolecular cycloadditions of photogenerated azaxylylenes tethered to pyrroles, with further growth of molecular complexity via post-photochemical transformations of primary photoproducts. This expeditious access to structurally unprecedented polyheterocyclic cores is being developed in the context of diversity-oriented synthesis, as the modular design allows for rapid "pre-assembly" of diverse photoprecursors from simple building blocks/diversity inputs.

SUBMITTER: Kumar NN 

PROVIDER: S-EPMC3763736 | biostudies-other | 2013 Jul

REPOSITORIES: biostudies-other