Unknown

Dataset Information

0

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (II).


ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major problem, causing severe and intractable infections worldwide. MRSA is resistant to all beta-lactam antibiotics, and alternative treatments are limited. A very limited number of new antibiotics have been discovered over the last half-century, novel agents for the treatment of MRSA infections are urgently needed. Marinopyrrole A was reported to show antibiotic activity against MRSA in 2008. After we reported the first total synthesis of (±)-marinopyrrole A, we designed and synthesized a series of marinopyrrole derivatives. Our structure activity relationship (SAR) studies of these novel derivatives against a panel of Gram-positive pathogens in antibacterial assays have revealed that a para-trifluoromethyl analog (33) of marinopyrrole A is ? 63-, 8-, and 4-fold more potent than vancomycin against methicillin-resistant Staphylococcus epidermidis (MRSE), methicillin-susceptible Staphylococcus aureus (MSSA) and MRSA, respectively. The results provide valuable information in the search for new-generation antibiotics.

SUBMITTER: Cheng C 

PROVIDER: S-EPMC3766874 | biostudies-other | 2013 Aug

REPOSITORIES: biostudies-other

altmetric image

Publications

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (II).

Cheng Chunwei C   Liu Yan Y   Song Hao H   Pan Lili L   Li Jerry J   Qin Yong Y   Li Rongshi R  

Marine drugs 20130815 8


Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major problem, causing severe and intractable infections worldwide. MRSA is resistant to all beta-lactam antibiotics, and alternative treatments are limited. A very limited number of new antibiotics have been discovered over the last half-century, novel agents for the treatment of MRSA infections are urgently needed. Marinopyrrole A was reported to show antibiotic activity against MRSA in 2008. After we reported the first total  ...[more]

Similar Datasets

| S-EPMC8446625 | biostudies-literature
| S-EPMC3719762 | biostudies-literature
| S-EPMC2889693 | biostudies-literature
| S-EPMC7071757 | biostudies-literature
| S-EPMC7461988 | biostudies-literature
| S-EPMC7318012 | biostudies-literature
| S-EPMC5849061 | biostudies-literature
| S-EPMC3528839 | biostudies-literature
| S-EPMC4068557 | biostudies-literature
| S-EPMC8459151 | biostudies-literature